ROME — Amid a global wave of anti-establishment anger, Italy may be the next in line for upheaval after a Sunday referendum that could topple Prime Minister Matteo Renzi and cast the nation into political crisis.

ROME — Amid a global wave of anti-establishment anger, Italy may be the next in line for upheaval after a Sunday referendum that could topple Prime Minister Matteo Renzi and cast the nation into political crisis.